10 bestCold Sore Treatmentsof April 2025
112M consumers helped this year.
9% off
1

Compeed Cold Sore Discreet Healing Patch, 15 Count (Pack of 1)
Compeed

9.9
24% off
2

Zovirax Cold Sore Treatment Cream, Pump Dispenser, 2 g, packaging may vary
Zovirax

9.8
3

Herpotherm Neo Cold Sore Treatment Device – Long Lasting and Reusable Heat Pen (Herpotherm neo)
Herpotherm

9.6
4

Carmex Lime Click Stick 4.25 g
Carmex

9.4
5

Carmex CLASSIC Moisturising Lip Balm Tube For Dry & Chapped Lips 10g
Carmex

9.1
OtherUp to 30% off
15% off
6

L-Lysine 2000mg | 180 Tablets | Essential Amino Acid | Premium Supplement | Vegan & Vegetarian | No Artificial Preservatives | by Horbaach
Horbäach

8.9
7

Virasorb Cold Sore Cream, Aciclovir 5%, 2g
Virasorb

8.6
8

L-Lysine 1100mg High Strength - 240 Vegan & Gluten Free Tablets (8 Month Supply) - Cold Sore Treatment, Essential Amino Acid Supplement - Normal Growth and Muscle Turnover - Made in The UK - Nutravita
Nutravita

8.4
5% off
9

Cymex Cream for Cold Sores x 2
Cymex

8.1
7% off
10

Bonjela Adult Gel 15g - Mint Oral Pain Relief For Mouth Ulcers, Cold Sores, Dentures - Fast 3-Minute Action, Fights Infections, Medication For Quick Comfort
Bonjela

7.8
A Guide to Selecting the Best Cold Sore Treatments
Cold sores, also known as fever blisters, are caused by the herpes simplex virus. They can be painful and unsightly, but there are various treatments available to help manage symptoms and speed up healing. When choosing a cold sore treatment, it's important to consider the type of treatment, its effectiveness, and how it fits into your lifestyle and needs. Here are some key specifications to look for when selecting a cold sore treatment.
Active Ingredients
Active ingredients are the components in a treatment that help to alleviate symptoms and promote healing. Common active ingredients in cold sore treatments include acyclovir, docosanol, and benzyl alcohol. Acyclovir and docosanol are antiviral agents that can help reduce the duration and severity of cold sores, while benzyl alcohol can provide pain relief. If you frequently get cold sores, you might want to choose a treatment with a strong antiviral ingredient. If pain is your main concern, look for treatments with pain-relieving ingredients.
Form of Treatment
Cold sore treatments come in various forms, including creams, gels, patches, and oral medications. Creams and gels are applied directly to the sore and can provide targeted relief. Patches can cover the sore, protect it from further irritation, and deliver medication over time. Oral medications are usually prescribed for more severe cases and work systemically to combat the virus. Consider your lifestyle and preferences when choosing the form of treatment. If you need discreet and continuous relief, patches might be ideal. If you prefer direct application, creams and gels are a good choice.
Application Frequency
The frequency with which you need to apply the treatment can vary. Some treatments require application several times a day, while others might only need to be applied once or twice. Treatments that need frequent application can be more effective but may be less convenient if you have a busy schedule. If you can commit to regular application, you might benefit from treatments that require frequent use. If you need something more convenient, look for treatments with less frequent application requirements.
Speed of Relief
The speed at which a treatment provides relief can be crucial, especially if you need to reduce symptoms quickly for an upcoming event or to minimize discomfort. Some treatments start working within hours, while others may take a day or two to show effects. If you need fast relief, look for treatments that are known for their quick action. If you can afford to wait a bit longer for relief, you might have more options to choose from.
Side Effects
Side effects are unwanted reactions that can occur with any medication. Common side effects of cold sore treatments can include skin irritation, dryness, or allergic reactions. It's important to read the label and understand the potential side effects before choosing a treatment. If you have sensitive skin or are prone to allergies, look for treatments with minimal side effects. If you are generally tolerant of medications, you might be able to use stronger treatments without issue.

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